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- IN01601
- 2025年07月23日
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- 详细信息
- 技术资料
- 保存条件：
Stroe at -20℃，6 months.
- 保质期：
Stroe at -20℃，6 months.
- 英文名：
Nifedipine(10mM in DMSO,Sterile）
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
21829-25-4
- 规格：
0.1ml/0.3ml/0.5ml/1.5ml/1ml
| 规格： | 0.1ml | 产品价格： | ￥120.0 |
|---|---|---|---|
| 规格： | 0.3ml | 产品价格： | ￥180.0 |
| 规格： | 0.5ml | 产品价格： | ￥240.0 |
| 规格： | 1.5ml | 产品价格： | ￥390.0 |
| 规格： | 1ml | 产品价格： | ￥300.0 |
| 基本信息 | |
| CAS | No.21829-25-4 |
| 中文名称 | 硝苯地平(10mM in DMSO,无菌） |
| 英文名称 | Nifedipine(10mM in DMSO,Sterile） |
| 分子式 | C17H18N2O6 |
| 分子量 | 346.33 |
| 溶解性 | 请根据自己的实验要求使用。 |
| 外观(性状) | 无菌溶液 |
| 储存条件 | Stroe at -20℃，6 months. |
| 靶点 | Calcium Channel |
| 通路 | Membrane Transporter&Ion Channel;Neuronal Signaling |
| 背景说明 | 是有效的钙离子通道 (calcium channel) 阻滞剂。 |
| 生物活性 | Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.[1-4] |
| In Vitro | Nifedipine (BAY-a-1040) (100 μM) significantly lowers the viability of the WKPT-0293 Cl.2 Cells， and treatment of nifedipine (10 or 100 μM) plus FAC induces a significant reduction in cell viability， but there are no significant differences in viability between the control cells and the cells treated with 100 μM of FAC or 1 and 10 μM of nifedipine.Nifedipine (BAY-a-1040) (1， 10， or 100 μM) significantly increases iron level in WKPT-0293 Cl.2 cells. Nifedipine treatment also increases expression of TfR1， DMT1+IRE and DMT1-IRE in WKPT-0293 Cl.2 cells. In addition， co-treatment with nifedipine (100 μM) and FAC (100 μM) increases TfR1， DMT1+IRE and DMT1-IRE expression in WKPT-0293 Cl.2 cells[2]. Nifedipine plus ritodrine produces a significantly greater inhibition of contractility than each drug alone in the midrange of concentrations. The combination of nifedipine plus nitroglycerin or nifedipine plus atosiban produces a significantly greater inhibition than nitroglycerin or atosiban alone but not greater than nifedipine. The combination of nifedipine plus NS-1619 (Ca2+-activated K+ [BKCa] channel opener) reduces the inhibitory effect of each drug[3]. Nifedipine (BAY-a-1040) (2 μM) significantly inhibits P. capsici mycelial growth and sporulation. Nifedipine (BAY-a-1040)-induced inhibition of mycelial growth is calcium-dependent. Nifedipine (0.5 μM) increases P. capsici sensitivity to H2O2 in a calcium-dependent manner[4]. |
| 细胞实验 | In Nifedipine (BAY-a-1040) (50 mg/kg)- and CsA-treated rats， the BL dimensions (BLi and BLk)， MD dimensions (MDk) and vertical dimensions (VHi and VHk) are significantly increased (P [1]. |
| 细胞实验 | Cell viability is assessed using an MTT assay. Briefly， a total of 25 μL MTT (1 g/L in PBS) is added to each well before incubation is conducted at 37°C for 4 h. The assay is stopped by the addition of a 100 μL lysis buffer (20% SDS in 50% N’Ndimethylformamide， pH 4.7). Optical density (OD) is measured at the 570 nm wavelength by the use of an ELX-800 microplate assay reader and the results are expressed as a percentage of the absorbance measured in the control cells.[1-4] |
| 动物实验 | All the 30 rats are randomLy distributed into three equal groups of ten animals each. Group 1 (control) receive olive oil for the 8 weeks. Group 2 and Group 3 receive a combination of CsA (30 mg/kg body weight) and Nf (50 mg/kg body weight) in olive oil for 8 weeks. In Group 3 rats， Azi (10 mg/kg body weight) is added to this regimen， in the 5th week. The total study period is 8 weeks.[1-4] |
| 数据来源文献 | [1]. Ratre MS， et al. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401. [2]. Carvajal JA， et al. The Synergic In Vitro Tocolytic Effect of Nifedipine Plus Ritodrine on Human Myometrial Contractility. Reprod Sci. 2017 Apr;24(4):635-640. [3]. Yu SS， et al. Nifedipine Increases Iron Content in WKPT-0293 Cl.2 Cells via Up-Regulating Iron Influx Proteins. Front Pharmacol. 2017 Feb 13;8:60 [4]. Liu P， et al. The L-type Ca(2+) Channel Blocker Nifedipine Inhibits Mycelial Growth， Sporulation， and Virulence of Phytophthora capsici. Front Microbiol. 2016 Aug 4;7:1236. |
| 单位 | 瓶 |
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IN01601 硝苯地平(10mM in DMSO,无菌） 跨膜转运/离子通道 索莱宝
￥120 - 390
