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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Stroe at -20℃，6 months.
- 保质期：
Stroe at -20℃，6 months.
- 英文名：
Piroxicam(10mM in DMSO,Sterile）
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
36322-90-4
- 规格：
0.1ml/0.3ml/0.5ml/1.5ml/1ml
| 规格： | 0.1ml | 产品价格： | ￥120.0 |
|---|---|---|---|
| 规格： | 0.3ml | 产品价格： | ￥180.0 |
| 规格： | 0.5ml | 产品价格： | ￥240.0 |
| 规格： | 1.5ml | 产品价格： | ￥390.0 |
| 规格： | 1ml | 产品价格： | ￥300.0 |
| 基本信息 | |
| CAS | No.36322-90-4 |
| 中文名称 | 吡罗昔康(10mM in DMSO,无菌） |
| 英文名称 | Piroxicam(10mM in DMSO,Sterile） |
| 分子式 | C15H13N3O4S |
| 分子量 | 331.35 |
| 溶解性 | 请根据自己的实验要求使用。 |
| 外观(性状) | 无菌溶液 |
| 储存条件 | Stroe at -20℃，6 months. |
| 靶点 | COX |
| 通路 | Immunology & Inflammation |
| 背景说明 | Piroxicam是一种非甾体抗炎剂，能够抑制 COX 的活性。 |
| 生物活性 | Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs， acts as a COX inhibitor， with IC50s of 47， 25 μM for human monocyte COX-1 and COX-2， respectively.[1-3] |
| In Vitro | Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs， acts as a COX inhibitor， with IC50s of 47， 25 μM for human monocyte COX-1 and COX-2， respectively[1]. Piroxicam (CP-16171) (167， 333， 500 μM) decreases cell population of T24 and the 5637 cells. Piroxicam (CP-16171) (500 μM) also reduces the cell viability of T24 and 5637 cell， and is significantly effective when combined with 0.05 μM carboplatin. The combination also inhibits Ki-67 expression in booth cells[3]. |
| 细胞实验 | Piroxicam (CP-16171) (0.3 mg/kg qd 24-h p.o.) reduces tumor volume in 12 of 18 dogs， and such and effect is via induction of apoptosis and reduction in urine basic fibroblast growth factor concentration[2]. |
| 细胞实验 | Urinary bladder cancer cell lines are treated with graded concentrations of carboplatin (0.05， 0.5 and 1 μM) and Piroxicam (CP-16171) (167， 333 and 500 μM) for 72 h to assess dose-response profiles. For the combination approach， 0.05 μM of carboplatin is used with 333 μM Piroxicam. Both drugs are freshly prepared before each experiment. An untreated control group (cells not exposed to carboplatin and Piroxicam) is used for all assays[3]. |
| 动物实验 | Dogs[2] Dogs undergo tumor staging， including thoracic and abdominal radiography， cystography， ultrasonography， and cystoscopy (with collection of tissue samples) before treatment and after 4 weeks of Piroxicam (CP-16171) (0.3 mg/kg qd 24-h p. o.) treatment. Dogs receive no other cancer treatment during the 4 weeks of Piroxicam (CP-16171) treatment. Tissue samples are immediately frozen in liquid nitrogen for PGE2 analysis or fixed in 10% neutral buffered formalin for immunohistochemical examination. Urine is also collected before and after Piroxicam treatment， aliquoted， and then stored at ?80°C until analyzed[2]. |
| 数据来源文献 | [1]. Kato M， et al. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol. 2001 Dec;53(12):1679-85. [2]. Mohammed SI， et al. Effects of the cyclooxygenase inhibitor， piroxicam， on tumor response， apoptosis， and angiogenesis in a canine model of human invasive urinary bladder cancer. Cancer Res. 2002 Jan 15;62(2):356-8. [3]. Silva J， et al. Synergistic Effect of Carboplatin and Piroxicam on Two Bladder Cancer Cell Lines. Anticancer Res. 2017 Apr;37(4):1737-1745. |
| 单位 | 瓶 |
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文献和实验1将有利于提取染色质蛋白1% SDS5 mM EDTA室温可保存1周使用前加入：Protease inhibitors、10mM DTT or beta-mercaptoethanol、15 U/ml DNase15、其它所需试剂：蛋白酶抑制剂Protease inhibitors ：推荐使用蛋白酶抑制剂cocktail，也可使用PMSF (50 ug/ml)和aprotinin (1 ug/ml).无菌PBS pH 7.4无菌PBS-BSA 1% (过滤处理)TBST缓冲液WB上样buffer
% ethanol; Vortex and precipitate at -80°C for 40 minutes; Centrifuge at 14000 rpm for 30 minutes at 4°C; Remove the supernatant and wash pellet with 200µl of cold 70% ethanol; Resuspend IP-DNA and INPUT samples in 50-100µl 10mM
液一般无细菌，而渗出液，尤以脓性者则大多数为感染性炎症所致。腹水中常见大肠杆菌、葡萄球菌、肺炎球菌、产气荚膜杆菌及绿脓杆菌、结核杆菌等。六、评价与问题 ㈠腹水常规检查：临床上将腹水一般性状、显微镜检查和粘蛋白定性试验简称为腹水常规检查，基本能够鉴别漏出液和渗出液，但由于引起腹水的病因很多，部分腹水标本难以定性，常常需要结合蛋白、糖定量检查，必要时在进行腹水酶学及免疫学检查。 ㈡恶性腹水的鉴别：恶性腹水主要是指原发或转移性肿瘤所致的腹水。腹水中检出肿瘤细胞是诊断的重要依据。腹水铁蛋白和溶菌
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