8-Nitroguanine

在炎症期间或体外，DNA中的鸟嘌呤碱基被RNS氧化损伤后形成的硝化鸟嘌呤衍生物；具有致突变性并诱导DNA中G:C到T:A的颠换；当以8-硝基G:抗-G碱基对的形式放入引物模板中时，会阻止人类DNA聚合酶β并诱导dA插入优先于dC，且插入优先度为2:1；在患有肺腺癌的K-Ras(G12V)突变小鼠的肺组织中以及在接触香烟烟雾的大鼠的肺组织和外周淋巴细胞DNA中，其含量增加；在流感或仙台病毒感染小鼠的肺组织中以及在IBD小鼠模型的结肠上皮细胞中，其含量增加。A nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by RNS during inflammation or in vitro; mutagenic and induces G:C to T:A transversion in DNA; stalls human DNA polymerase β and induces a 2:1 preference dA insertion over dC when placed into a primer template as an 8-nitroG:anti-G base pair; levels are increased in the lung tissue of mice with mutant K-Ras(G12V) that developed lung adenocarcinoma and in the lung tissue and peripheral lymphocyte DNA of cigarette smoke-exposed rats; levels are increased in the lung tissue of influenza or Sendai virus-infected mice and in colon epithelial cells of an IBD mouse model.分子式C5H4N6O3分子量196.1O=C1C2=C(N=C([N+]([O-])=O)N2)N=C(N)N1