Curcumin (technical grade)

一种具有多种生物活性的黄色色素；抑制NO生成(IC50=6μM)并降低LPS刺激的RAW 264.7细胞中的iNOS活性；抑制HMC-1肥大细胞释放组胺和炎性细胞因子TNF-α、IL-1β、IL-6和IL-8；降低血清中组胺和TNF-α的水平，抑制鼻粘膜的组织病理学变化，减少小鼠卵清蛋白诱发的鼻炎模型中打喷嚏和揉鼻的次数；防止卵清蛋白诱导的3-NT在小鼠心脏中的积累；减少TPA诱导的小鼠皮肤肿瘤形成(1-10μmol)；减少4-NQO诱发的大鼠舌肿瘤和癌前病变的数量。A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats.分子式C21H20O6分子量368.4O=C(CC(/C=C/C1=CC(OC)=C(O)C=C1)=O)/C=C/C2=CC(OC)=C(O)C=C2