- ￥3596
- LSM BIO
- 进口
- PAab10146
- 2025年07月16日
- ELISA, WB, IHC
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
programmed cell death 10
- 亚型：
IgG1
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
monoclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Mouse
- 目录编号：
P04085
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, WB, IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
programmed cell death 10
- 抗体英文名：
EGFR antibody
- 抗体名：
EGFR antibody|EGFR 抗体
- 规格：
100μl
EGFR antibody
Product Name EGFR antibody
Catalog No PAab10146
Packing 100ug
Form liquid
Alternative Name EGFR, ERBB, ERBB1, HER1, mENA, PIG61, Proto oncogene c ErbB 1
Purification protein A+G purified
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG1
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Immunogen epidermal growth factor receptor
Specificity Human
Tested Application ELISA, WB, IHC
Recommended dilution WB: 1:2000 - 1:10000; IHC: 1:100 - 1:1000
IHC use Immunohistochemistry of paraffin-embedded human lung cancer slide using PAab10146( EGFR Antibody) at dilution of 1:500
WB use
PC-3 cells were subjected to SDS PAGE followed by western blot with PAab10146( EGFR Antibody) at dilution of 1:5000
Protein Information
Gene ID 1956
Uniprot ID P00533
Calculated MW 140-160 kDa
Research Area Signal Transduction, Immunology, Cancer
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文献和实验受体阳性的乳腺癌细胞有较小程度的细胞毒性，这种情况与在异种移植小鼠模型中的表现一致。体外实验中，在 TNBC 细胞的诱导下，初始 EGFR CAR-T 迅速扩增，同时还会激活 interferomγ, granzyme-perforin-PARP 和 FaS-FADD-caspase 等相关信号通路。 实验团队首先通过免疫印迹和流式细胞术的方法验证 EGFR 高表达于三阴乳腺癌。其中免疫印迹（immunoblotting）又称蛋白质印迹（Western blotting），是根据抗原抗体的特异性结合检测
Clinical Advancement of EGFR Inhibitors in Cancer Therapy
The epidermal growth factor receptor (EGFR) represents one of the most promising molecular targets in cancer therapeutics. An array of EGFR inhibitory drugs have been developed that are progressing rapidly in oncology clinical trials
Phosphotyrosine Kinase Assays as a Prescreen for Inhibitors of EGFr
The epidermal growth factor receptor (EGFr) is a 170-kDa glycosylated transmembrane protein found in a wide variety of tissues (1 ). It is the receptor for epidermal growth factor (EGF), transforming growth factor α (TGFα), and other related
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