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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
heat shock protein 90kDa alpha(cytosolic), class A member 1
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
polyclonal
- 标记物:
Non-conjugated
- 适应物种:
Human, Mouse, Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
Q9BZJ3
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA, IHC, WB
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
heat shock protein 90kDa alpha(cytosolic), class A member 1
- 抗体英文名:
HSP90AA1 antibody
- 抗体名:
HSP90AA1 antibody
- 规格:
100μl
HSP90AA1 antibody
Product Name HSP90AA1 antibody
Catalog No PAab09974
Packing 100ul
Form liquid
Alternative Name HSP 86, HSP86, Hsp89, HSP89A, HSP90, HSP90A, HSP90AA1, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
HSP90, encoded by HSP90AA1, is a constitutively and ubiquitously expressed molecular chaperone that is crucial for the stability and function of many proteins. HSP90 provides chaperoning activity for client proteins; many of them are members of oncogenic pathways, indicating its implication in tumor malignancy. HSP90 mainly resides in the cytosol, while it can also be released to the extracellular space. Secreted Hsp90 is a C-terminal truncated form. It has been reported that the level of plasma Hsp90 is positively correlated with tumor malignancy in clinical cancer patients, and can be a promising diagnostic marker for tumor malignancy in clinical application.
Immunogen heat shock protein 90kDa alpha(cytosolic), class A member 1
Specificity Human, Mouse, Rat
Tested Application ELISA, IHC, WB
Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:200
IHC use Immunohistochemistry of paraffin-embedded rat testis using PAab09974(HSP90AA1 antibody) at dilution of 1:100
WB use
HeLa cells were subjected to SDS PAGE followed by western blot with PAab09974(HSP90AA1 Antibody) at dilution of 1:1000
Protein Information
Gene ID 3320
Uniprot ID P07900
Calculated MW 100 kDa
Research Area Cancer, Signal Transduction
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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