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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Huntingtin
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
polyclonal
- 标记物:
Non-conjugated
- 适应物种:
Human, Mouse
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
Q9BZJ3
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA, IF, IHC
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
Huntingtin
- 抗体英文名:
Huntingtin antibody
- 抗体名:
Huntingtin antibody
- 规格:
100μl
Huntingtin antibody
Product Name Huntingtin antibody
Catalog No PAab09844
Packing 100ul
Form liquid
Alternative Name HD, HD protein, HTT, Huntingtin, Huntington disease protein, IT15
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
HTT(huntingtin), also named as HD and IT15, belongs to the huntingtin family. HTT may play a role in microtubule-mediated transport or vesicle function. Defects in HTT are the cause of Huntington disease (HD) which is an autosomal dominant neurodegenerative disorder characterized by involuntary movements (chorea), general motor impairment, psychiatric disorders and dementia.
Immunogen Huntingtin
Specificity Human, Mouse
Tested Application ELISA, IF, IHC
Recommended dilution IHC: 1:50-1:500; IF: 1:50-1:500
IHC use Immunohistochemistry of paraffin-embedded rat brain tissue slide using PAab09844( Huntingtin antibody) at dilution of 1:200
WB use
Protein Information
Gene ID 3064
Uniprot ID P42858
Calculated MW 50 kDa
Research Area Neuroscience
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文献和实验has produced monoclonal and recombinant single-chain antibodies that can be used for each of these purposes with huntingtin. This is the protein that, when mutated to contain an expanded polyQ motif, causes Huntington’s disease.
complexes. In the context of huntingtin (Htt), antibodies can distinguish Htt with normal or an expanded polyglutamine (polyQ) repeats, and they can identify distinct conformations of Htt. Htt is the protein that, when mutated to contain an expanded polyQ
misfolded proteins in native settings. In this book chapter we describe simple and sensitive detection methods to characterize high ordered aggregates (AGERA) and subsets of distinct soluble aggregates (SEC-FRET) of mutant huntingtin
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