- ￥2260
- LSM Bio
- 进口
- PAab10091
- 2025年07月14日
- ELISA, IHC
- E. coli - derived recombinant protein
- Human, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Rho guanine nucleotide exchange factor(GEF) 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human, Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
Rho guanine nucleotide exchange factor(GEF) 1
- 抗体英文名：
ARHGEF1 antibody
- 抗体名：
ARHGEF1 antibody
- 规格：
100μl
ARHGEF1 antibody
Product Name ARHGEF1 antibody
Catalog No PAab10091
Packing 100ul
Form liquid
Alternative Name ARHGEF1, GEF1, LBCL2, LSC, P115 RHOGEF, p115RhoGEF, SUB1.5, ARHG1
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12(GNA12) and alpha-13(GNA13) subunits. Acts as GTPase-activating protein(GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor(GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Immunogen Rho guanine nucleotide exchange factor(GEF) 1
Specificity Human, Rat
Tested Application ELISA, IHC
Recommended dilution IHC: 1:20-1:200
IHC use Immunohistochemistry of paraffin-embedded rat lung using PAab10091(PER2 antibody) at dilution of 1:50
WB use
Protein Information
Gene ID 9138
Uniprot ID Q92888
Calculated MW 102-110 kDa
Research Area Signal Transduction, Metabolism
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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