2',3'-cGAMP-iFluor 647 偶联物

2',3'-cGAMP-iFluor 647 偶联物

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  • ¥9850
  • AAT Bioquest
  • 进口
  • 20322
  • 2025年07月15日
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    • 详细信息
    • 技术资料
    • 英文名

      2’,3’-cGAMP-iFluor 647 conjugate

    • 库存

      50

    • 供应商

      广州市左克生物科技发展有限公司

    • 规格

      100ug

    产品参数
    Ex (nm) 656 Em (nm) 670
    分子量 N/A 溶剂 DMSO
    存储条件 在零下15度以下保存
    产品概述

    产品基本信息

    产品名称:2',3'-cGAMP-iFluor 647 偶联物

    储存条件:-15℃避光防潮

    保质期:12个月

     

    产品物理化学光谱特性

    分子量:~2000

    外观:固体

    溶剂:DMSO

    激发波长(nm):656

    发射波长(nm):670

     

    产品介绍

    iFluor® 647 标记的 cGAMP 提供了一种出色的荧光探针,可用于开发基于荧光的检测和测试以检测 cGAMP 或监测其活性。 iFluor® 647 偶联物可被红色激光很好地激发,并且可以使用常用的 Cy5 滤光片组进行监测。此外,iFluor® 647 的荧光不受 pH (4-10) 的影响。 2',3'-cGAMP 近年来因其作为癌症和病毒感染等疾病治疗靶点的潜力而受到广泛关注。它已被证明可以激活免疫系统并增强免疫检查点抑制剂的功效,这是一种癌症免疫疗法。 2',3'-cGAMP(环状 GMP-AMP)是一种环状二核苷酸第二信使分子,在先天免疫系统中起着至关重要的作用。它由酶 cGAS(环状 GMP-AMP 合酶)合成,以响应从受损或感染细胞中释放的胞质 DNA。一旦合成,2',3'-cGAMP 就会与衔接蛋白 STING(干扰素基因刺激物)结合并触发下游信号通路,从而产生 I 型干扰素和其他细胞因子,从而导致针对入侵病原体的免疫反应。

    点击查看光谱

     

    参考文献

    Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.
    Authors: Gupta, Urvi and Ghosh, Sayan and Wallace, Callen T and Shang, Peng and Xin, Ying and Nair, Archana Padmanabhan and Yazdankhah, Meysam and Strizhakova, Anastasia and Ross, Mark A and Liu, Haitao and Hose, Stacey and Stepicheva, Nadezda A and Chowdhury, Olivia and Nemani, Mihir and Maddipatla, Vishnu and Grebe, Rhonda and Das, Manjula and Lathrop, Kira L and Sahel, José-Alain and Zigler, J Samuel and Qian, Jiang and Ghosh, Arkasubhra and Sergeev, Yuri and Handa, James T and St Croix, Claudette M and Sinha, Debasish
    Journal: Autophagy (2023): 92-111
     
    Naringenin is a Potential Immunomodulator for Inhibiting Liver Fibrosis by Inhibiting the cGAS-STING Pathway.
    Authors: Chen, Li and Xia, Siwei and Wang, Shuqi and Zhou, Yuanyuan and Wang, Feixia and Li, Zhanghao and Li, Yang and Kong, Desong and Zhang, Zili and Shao, Jiangjuan and Xu, Xuefen and Zhang, Feng and Zheng, Shizhong
    Journal: Journal of clinical and translational hepatology (2023): 26-37
     
    Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cth GAMP.
    Authors: Veth, Simon and Fuchs, Adrian and Özdemir, Dilara and Dialer, Clemens and Drexler, David Jan and Knechtel, Fabian and Witte, Gregor and Hopfner, Karl-Peter and Carell, Thomas and Ploetz, Evelyn
    Journal: Chembiochem : a European journal of chemical biology (2022): e202200005
     
    Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis.
    Authors: Duan, Na and Zhang, Yanpeng and Tan, Shuwen and Sun, Jianyu and Ye, Mao and Gao, Hui and Pu, Kairui and Wu, Meiyan and Wang, Qiang and Zhai, Qian
    Journal: Neurobiology of disease (2022): 105739
     
    Mechanisms of phase-separation-mediated cGAS activation revealed by dcFCCS.
    Authors: Yao, Yirong and Wang, Wenjuan and Chen, Chunlai
    Journal: PNAS nexus (2022): pgac109
     
    Development of a High-Throughput Assay to Identify Inhibitors of ENPP1.
    Authors: Kumar, Meera and Lowery, Robert G
    Journal: SLAS discovery : advancing life sciences R & D (2021): 740-746
     
    Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics.
    Authors: Jindal, Shlok and Chockalingam, S and Ghosh, Siddhartha Sankar and Packirisamy, Gopinath
    Journal: Translational research : the journal of laboratory and clinical medicine (2021): 144-167
     
    Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase.
    Authors: Abdisalaam, Salim and Bhattacharya, Souparno and Mukherjee, Shibani and Sinha, Debapriya and Srinivasan, Kalayarasan and Zhu, Mingrui and Akbay, Esra A and Sadek, Hesham A and Shay, Jerry W and Asaithamby, Aroumougame
    Journal: The Journal of biological chemistry (2020): 11144-11160
     
    Development of novel highly sensitive methods to detect endogenous cGAMP in cells and tissue.
    Authors: Miyakawa, Shuuichi and Okui, Toshitake and Shiraishi, Tsubasa and Yoshihara, Tomoki and Hirayama, Megumi and Satomi, Yoshinori and Hamada, Teruki and Nishida, Mayumi and Akimoto, Chihiro and Sato, Shuji
    Journal: Journal of immunological methods (2020): 112751
     
    [Effect of cyclic GMP-AMP synthase on EMT in breast cancer cells].
    Authors: Zhang, Xiao-Jin and Zhang, Wen-Xia and Zhu, Ji-Ling and Luo, Wen-Pan
    Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (2020): 336-339

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