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- 详细信息
- 技术资料
- 英文名：
2’,3’-cGAMP-iFluor 488 conjugate
- 库存：
50
- 供应商：
广州市左克生物科技发展有限公司
- 规格：
100ug
产品参数
| Ex (nm) | 491 | Em (nm) | 516 |
| 分子量 | N/A | 溶剂 | DMSO |
| 存储条件 | 在零下15度以下保存, 避免光照 |
产品概述
产品基本信息
产品名称：2',3'-cGAMP-iFluor 488 偶联物
储存条件：-15℃避光防潮
保质期：12个月
产品物理化学光谱特性
分子量：1834.96
外观：固体
溶剂：DMSO
激发波长(nm)：491
发射波长(nm)：516
产品介绍
iFluor 488 标记的 cGAMP 提供了一种出色的荧光探针，可用于开发基于荧光的检测和测试以检测 cGAMP 或监测其活性。 iFluor 488 偶联物比荧光素偶联物更亮，并且光稳定性更高。此外，iFluor 488 的荧光不受 pH (4-10) 的影响。 2',3'-cGAMP 近年来因其作为癌症和病毒感染等疾病治疗靶点的潜力而受到广泛关注。它已被证明可以激活免疫系统并增强免疫检查点抑制剂的功效，这是一种癌症免疫疗法。 2',3'-cGAMP（环状 GMP-AMP）是一种环状二核苷酸第二信使分子，在先天免疫系统中起着至关重要的作用。它由酶 cGAS（环状 GMP-AMP 合酶）合成，以响应从受损或感染细胞中释放的胞质 DNA。一旦合成，2',3'-cGAMP 就会与衔接蛋白 STING（干扰素基因刺激物）结合并触发下游信号通路，从而产生 I 型干扰素和其他细胞因子，从而导致针对入侵病原体的免疫反应。
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溶解方案(溶剂以说明书为准)
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 54.497 µL | 272.486 µL | 544.971 µL | 2.725 mL | 5.45 mL |
| 5 mM | 10.899 µL | 54.497 µL | 108.994 µL | 544.971 µL | 1.09 mL |
| 10 mM | 5.45 µL | 27.249 µL | 54.497 µL | 272.486 µL | 544.971 µL |
参考文献
Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity.
Authors: Zhang, Conggang and Han, Jing and Hu, Shuiqing and Hu, Yawei and Xu, Yifang and Hou, Yanfei and Yang, Yinlong and Su, Huili and Zhang, Zhengyin and Liu, Peng and Sun, Xuxu
Journal: Cancer immunology research (2023)
Authors: Zhang, Conggang and Han, Jing and Hu, Shuiqing and Hu, Yawei and Xu, Yifang and Hou, Yanfei and Yang, Yinlong and Su, Huili and Zhang, Zhengyin and Liu, Peng and Sun, Xuxu
Journal: Cancer immunology research (2023)
Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease.
Authors: Riederer, Stephanie and Del Canizo, Ana and Navas, Javier and Peter, Marlowe G and Link, Ellen K and Sutter, Gerd and Rojas, Juan J
Journal: Cancer gene therapy (2023)
Authors: Riederer, Stephanie and Del Canizo, Ana and Navas, Javier and Peter, Marlowe G and Link, Ellen K and Sutter, Gerd and Rojas, Juan J
Journal: Cancer gene therapy (2023)
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.
Authors: Gentili, Matteo and Liu, Bingxu and Papanastasiou, Malvina and Dele-Oni, Deborah and Schwartz, Marc A and Carlson, Rebecca J and Al'Khafaji, Aziz M and Krug, Karsten and Brown, Adam and Doench, John G and Carr, Steven A and Hacohen, Nir
Journal: Nature communications (2023): 611
Authors: Gentili, Matteo and Liu, Bingxu and Papanastasiou, Malvina and Dele-Oni, Deborah and Schwartz, Marc A and Carlson, Rebecca J and Al'Khafaji, Aziz M and Krug, Karsten and Brown, Adam and Doench, John G and Carr, Steven A and Hacohen, Nir
Journal: Nature communications (2023): 611
Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity.
Authors: Zhou, Yajun and Lu, Xing and Wang, Xiaoqing and Ying, Tianlei and Tan, Xiangshi
Journal: International journal of molecular sciences (2023)
Authors: Zhou, Yajun and Lu, Xing and Wang, Xiaoqing and Ying, Tianlei and Tan, Xiangshi
Journal: International journal of molecular sciences (2023)
cGAMP-activated cGAS-STING signaling: its bacterial origins and evolutionary adaptation by metazoans.
Authors: Patel, Dinshaw J and Yu, You and Xie, Wei
Journal: Nature structural & molecular biology (2023): 245-260
Authors: Patel, Dinshaw J and Yu, You and Xie, Wei
Journal: Nature structural & molecular biology (2023): 245-260
Proteomic and phosphoproteomic analyses of Jurkat T-cell treated with 2'3' cGAMP reveals various signaling axes impacted by cyclic dinucleotides.
Authors: Onyedibe, Kenneth I and Mohallem, Rodrigo and Wang, Modi and Aryal, Uma K and Sintim, Herman O
Journal: Journal of proteomics (2023): 104869
Authors: Onyedibe, Kenneth I and Mohallem, Rodrigo and Wang, Modi and Aryal, Uma K and Sintim, Herman O
Journal: Journal of proteomics (2023): 104869
cGAS/cGAMP/STING signal propagation in the tumor microenvironment: Key role for myeloid cells in antitumor immunity.
Authors: Mekers, Vera E and Kho, Vera M and Ansems, Marleen and Adema, Gosse J
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2022): 158-167
Authors: Mekers, Vera E and Kho, Vera M and Ansems, Marleen and Adema, Gosse J
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2022): 158-167
Synthesis, Formulation and Characterization of Immunotherapeutic Glycosylated Dendrimer/cGAMP Complexes for CD206 Targeted Delivery to M2 Macrophages in Cold Tumors.
Authors: Petrovic, Marija and Porcello, Alexandre and Tankov, Stoyan and Majchrzak, Oliwia and Kiening, Martin and Laingoniaina, Annick Clara and Jbilou, Tayeb and Walker, Paul R and Borchard, Gerrit and Jordan, Olivier
Journal: Pharmaceutics (2022)
Authors: Petrovic, Marija and Porcello, Alexandre and Tankov, Stoyan and Majchrzak, Oliwia and Kiening, Martin and Laingoniaina, Annick Clara and Jbilou, Tayeb and Walker, Paul R and Borchard, Gerrit and Jordan, Olivier
Journal: Pharmaceutics (2022)
ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling.
Authors: Carozza, Jacqueline A and Cordova, Anthony F and Brown, Jenifer A and AlSaif, Yasmeen and Böhnert, Volker and Cao, Xujun and Mardjuki, Rachel E and Skariah, Gemini and Fernandez, Daniel and Li, Lingyin
Journal: Proceedings of the National Academy of Sciences of the United States of America (2022): e2119189119
Authors: Carozza, Jacqueline A and Cordova, Anthony F and Brown, Jenifer A and AlSaif, Yasmeen and Böhnert, Volker and Cao, Xujun and Mardjuki, Rachel E and Skariah, Gemini and Fernandez, Daniel and Li, Lingyin
Journal: Proceedings of the National Academy of Sciences of the United States of America (2022): e2119189119
Protocol for identification and validation of 2'3'-cGAMP-binding proteins by photoaffinity probes.
Authors: Hou, Yingjie and Lu, Heng and Sun, Le and Zhang, Yaoyang and Jiang, Hong
Journal: STAR protocols (2022): 101076
Authors: Hou, Yingjie and Lu, Heng and Sun, Le and Zhang, Yaoyang and Jiang, Hong
Journal: STAR protocols (2022): 101076
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2',3'-cGAMP-iFluor 488 偶联物
￥9850
