- ￥2860
- LSM Bio
- 进口
- PAab09441
- 2025年07月16日
- ELISA
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
vacuolar protein sorting 39 homolog (S. cerevisiae)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
vacuolar protein sorting 39 homolog (S. cerevisiae)
- 抗体英文名：
anti-VPS39 antibody,VPS39 antibody
- 抗体名：
anti-VPS39 抗体,VPS39 抗体
- 规格：
100μl
VPS39抗体| VPS39 antibody
货号 PAab09441
蛋白别名 FLJ21681 antibody, FLJ46546 antibody, hVam6p antibody, KIAA0770 antibody, TLP antibody, VAM6 antibody, Vam6/Vps39 like protein antibody, VPS39
蛋白介绍
Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed:11448994, PubMed:23351085, PubMed:23167963). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203).
产品描述
anti-VPS39 antibody is a Rabbit Polyclonal antibody againstVPS39..
建议稀释比例
IP:1:200-1:1000
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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