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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
ubiquitin-conjugating enzyme E2S
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
Q9BZJ3
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC,FC,IP
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
ubiquitin-conjugating enzyme E2S
- 抗体英文名:
anti-UBE2S antibody,UBE2S antibody
- 抗体名:
anti-UBE2S 抗体,UBE2S 抗体
- 规格:
100μl
UBE2S抗体| UBE2S antibody
货号 PAab09183
蛋白别名 E2 EPF antibody, E2EPF antibody, EPF5 antibody, UBE2S antibody, Ubiquitin carrier protein S antibody, Ubiquitin protein ligase S
蛋白介绍
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
产品描述
anti-UBE2S antibody is a Rabbit Polyclonal antibody againstUBE2S..
建议稀释比例
WB : 1:200-1:2000;IP:1:500-1:5000;IHC:1:20-1:200
IHC
Immunohistochemistry of paraffin-embedded human breast cancer using PAab09183(UBE2S antibody) at dilution of 1:50
Western blot
MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with PAab09183(UBE2S antibody) at dilution of 1:500(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验
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