- ￥2260
- LSM Bio
- 进口
- PAab09168
- 2025年07月15日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
- 抗体英文名：
anti-UBE2D3 antibody,UBE2D3 antibody
- 抗体名：
anti-UBE2D3 抗体,UBE2D3 抗体
- 规格：
100μl
UBE2D3抗体| UBE2D3 antibody
货号 PAab09168
蛋白别名 E2(17)KB3 antibody, UBC4/5 antibody, UBC5C antibody, UBCH5C antibody, UBE2D3 antibody, Ubiquitin carrier protein D3 antibody, Ubiquitin protein ligase D3
蛋白介绍
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML- NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.
产品描述
anti-UBE2D3 antibody is a Rabbit Polyclonal antibody againstUBE2D3..
建议稀释比例
WB : 1:1000-1:10000;IHC:1:20-1:200
IHC
Immunohistochemistry of paraffin-embedded human prostate cancer using PAab09168(UBE2D3 antibody) at dilution of 1:100
Western blot
human brain tissue were subjected to SDS PAGE followed by western blot with PAab09168(UBE2D3 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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