- ￥2260
- LSM Bio
- 进口
- PAab09038
- 2025年07月15日
- ELISA,WB
- E. coli - derived recombinant protein
- Human, Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
- 抗体英文名：
anti-TSEN2 antibody,TSEN2 antibody
- 抗体名：
anti-TSEN2 抗体,TSEN2 抗体
- 规格：
100μl
TSEN2抗体| TSEN2 antibody
货号 PAab09038
蛋白别名 HsSen2 antibody, PCH2B antibody, SEN2 antibody, SEN2L antibody, tRNA intron endonuclease Sen2 antibody, TSEN2
蛋白介绍
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre- mRNA 3'-end processing factors, establishing a link between pre- tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
产品描述
anti-TSEN2 antibody is a Rabbit Polyclonal antibody againstTSEN2..
建议稀释比例
WB:1:500-1:5000
IHC
Western blot
human brain tissue were subjected to SDS PAGE followed by western blot with PAab09038(TSEN2 antibody) at dilution of 1:400(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验施一公团队再获新进展！解析人类 pre-tRNA 剪接机制，完善剪接体结构「地图」
步骤产生，从 pre-tRNA 中去除内含子对于生物遗传进化是必不可少的。 在人类中，去除 pre-tRNA 中内含子的过程是由 tRNA 剪接内切核酸酶（TSEN）介导的，该亚酶包括四个亚基：TSEN2、TSEN15、TSEN34 和 TSEN54。值得一提的是，尽管多核苷酸激酶 CLP1 在体外对前 tRNA 切割是可有可无的，但 CLP1 中的突变和所有 TSEN 亚基都与 tRNA 代谢和神经病理学的改变有关。 为回答 pre-tRNA 是如何被 TSEN 识别的，以及 5' 剪接
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