- ￥2262
- LSM Bio
- 进口
- PAab08598
- 2025年07月16日
- ELISA,WB
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
telomeric repeat binding factor 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
telomeric repeat binding factor 2
- 抗体英文名：
anti-TERF2 antibody,TERF2 antibody
- 抗体名：
anti-TERF2 抗体,TERF2 抗体
- 规格：
100μg
TERF2抗体| TERF2 antibody
货号 PAab08598
蛋白别名 TRBF2 antibody, TRF2
蛋白介绍
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single- stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology- directed repair (HDR), which can affect telomere length.
产品描述
anti-TERF2 antibody is a Rabbit Polyclonal antibody againstTERF2..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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