- ￥2262
- LSM Bio
- 进口
- PAab07538
- 2025年07月15日
- ELISA,WB,IHC,IP,IF
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
RuvB-like 2 (E. coli)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
RuvB-like 2 (E. coli)
- 抗体英文名：
anti-RUVBL2 antibody,RUVBL2 antibody
- 抗体名：
anti-RUVBL2 抗体,RUVBL2 抗体
- 规格：
100μg
RUVBL2抗体| RUVBL2 antibody
货号 PAab07538
蛋白别名 INO80J antibody, TIP48 antibody, TIP49B
蛋白介绍
Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.
产品描述
anti-RUVBL2 antibody is a Rabbit Polyclonal antibody againstRUVBL2..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human testis using PAab07538(RUVBL2 antibody) at dilution of 1:50
Western blot
K-562 cells were subjected to SDS PAGE followed by western blot with PAab07538(RUVBL2 antibody) at dilution of 1:800(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
sapiens replication protein A2, 32kDa (RPA2), mRNA 537 NM_004356 Homo sapiens CD81 antigen (target of antiproliferative antibody 1) (CD81), mRNA 3638 NM_001743 Homo sapiens calmodulin 2 (phosphorylase kinase, delta) (CALM2), mRNA 4675 NM_004231
所有的看家基因(housekeeping genes)的列表+引物设计服务
Homo sapiens RuvB-like 2 (E. coli) (RUVBL2), mRNA 690 NM_005219 Homo sapiens diaphanous homolog 1 (Drosophila) (DIAPH1), mRNA 592 NM_033546 Homo sapiens myosin regulatory light
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