- ￥2262
- LSM Bio
- 进口
- PAab07471
- 2025年07月16日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
ribosomal protein S27a
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
ribosomal protein S27a
- 抗体英文名：
anti-RPS27A antibody,RPS27A antibody
- 抗体名：
anti-RPS27A 抗体,RPS27A 抗体
- 规格：
100μg
RPS27A抗体| RPS27A antibody
货号 PAab07471
蛋白别名 UBA80 antibody, UBCEP1
蛋白介绍
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. 40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.
产品描述
anti-RPS27A antibody is a Rabbit Polyclonal antibody againstRPS27A..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human endometrial cancer tissue slide using PAab07471( RPS27A Antibody) at dilution of 1:50
Western blot
mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with PAab07471(RPS27A antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验Nat Commun：肖东/孙妍课题组合作揭示 m6A 修饰调节细胞自噬的新机制
1 YTHDF3 上调对诱导自噬至关重要 （图源：Hao WC, et al., Nat Commun, 2022） METTL3 是 mRNA 的 m6A 甲基化修饰酶。研究表明，METTL3 表达与其 m6A 修饰酶活性在营养缺乏时均明显上调（图 2a-f），而 METTL3 功能缺失可引起饥饿诱导的功能性 m6A 甲基化修饰抑制并降低 YTHDF3 介导的自噬流（图 2 h-m）。接着，研究者探讨了饥饿导致 METTL3 m6A 修饰酶活性及其表达升高的分子机制，发现泛素-核糖体蛋白融合蛋白 RPS27a
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
(GAPD), mRNA 828 *NM_000291 Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA 2727 *NM_005566 Homo sapiens lactate dehydrogenase A (LDHA), mRNA 2105 *NM_002954 Homo sapiens ribosomal protein S27a (RPS27A), mRNA 4156 *NM_000981 Homo sapiens
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