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- LSM Bio
- 进口
- PAab07393
- 2025年07月14日
- ELISA
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
replication protein A3, 14kDa
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
replication protein A3, 14kDa
- 抗体英文名：
anti-RPA3 antibody,RPA3 antibody
- 抗体名：
anti-RPA3 抗体,RPA3 抗体
- 规格：
100μg
RPA3抗体| RPA3 antibody
货号 PAab07393
蛋白别名 REPA3 antibody, RPA14
蛋白介绍
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).
产品描述
anti-RPA3 antibody is a Rabbit Polyclonal antibody againstRPA3..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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）的增殖和分化，并调节成熟少突胶质细胞的髓磷脂可塑性。 为了更深入地了解年轻的脑脊液在 OPCs 中诱导中的作用，他们对用年轻人脑脊液（YH-CSF）处理后的 OPCs 进行转录组学和代谢组学的分析。发现血清反应因子（Serum Response Factor, SRF）显著上调，SRF 可以通过调节肌动蛋白细胞骨架等来诱导细胞运动、增殖和分化。此外，他们还注意到 Wnt 信号负调控因子、促凋亡因子 Bcl7b 和 DNA 修复蛋白 Rpa3 的显著下调。 接下来，为了检测测试 CSF 诱导
胶质细胞祖细胞（OPCs）的增殖和分化，并调节成熟少突胶质细胞的髓磷脂可塑性。 为了更深入地了解年轻的脑脊液在 OPCs 中诱导中的作用，他们对用年轻人脑脊液（YH-CSF）处理后的 OPCs 进行转录组学和代谢组学的分析。发现血清反应因子（Serum Response Factor, SRF）显著上调，SRF 可以通过调节肌动蛋白细胞骨架等来诱导细胞运动、增殖和分化。此外，他们还注意到 Wnt 信号负调控因子、促凋亡因子 Bcl7b 和 DNA 修复蛋白 Rpa3 的显著下调。 接下来，为了检测
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