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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
RecQ protein-like 5
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human, Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC,IF
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
RecQ protein-like 5
- 抗体英文名:
anti-RECQL5 antibody,RECQL5 antibody
- 抗体名:
anti-RECQL5 抗体,RECQL5 抗体
- 规格:
100μg
RECQL5抗体| RECQL5 antibody
货号 PAab07227
蛋白别名 RECQ5
蛋白介绍
Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.
产品描述
anti-RECQL5 antibody is a Rabbit Polyclonal antibody againstRECQL5..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human pancreas cancer using PAab07227(RECQL5 antibody) at dilution of 1:50
Western blot
mouse testis tissue were subjected to SDS PAGE followed by western blot with PAab07227(RECQL5 antibody) at dilution of 1:1000(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验Recql5是哺乳动物RecQ解旋酶家族成员之一。基因突变导致的RecQ解旋酶失活,会引起癌症易感性及早老化相关的问题,诸如Bloom、Werner和Rothmund-Thomson综合症。这种酶类在维持基因组的完整性以防止致癌突变的作用众所周知。 2010年3月28日发表在《World Journal of Gastroenterology》一篇研究论文阐述了这个问题。在Case Western Reserve 大学的研究小组研究了这个解旋酶是否在抑制胃肠道肿瘤中发挥作用,但这不能仅仅
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