- ￥2262
- LSM Bio
- 进口
- PAab07171
- 2025年07月16日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
RNA binding motif protein 25
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
RNA binding motif protein 25
- 抗体英文名：
anti-RBM25 antibody,RBM25 antibody
- 抗体名：
anti-RBM25 抗体,RBM25 抗体
- 规格：
100μg
RBM25抗体| RBM25 antibody
货号 PAab07171
蛋白别名 RNPC7
蛋白介绍
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
产品描述
anti-RBM25 antibody is a Rabbit Polyclonal antibody againstRBM25..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab07171( RBM25 Antibody) at dilution of 1:50
Western blot
Jurkat cells were subjected to SDS PAGE followed by western blot with PAab07171( RBM25 Antibody) at dilution of 1:600(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验启动子和增强子区域。更令人惊讶的是，该研究虽然只检测了人类基因组中一小部分的 RNA 结合蛋白（这项研究还重点阐释了 RNA 结合蛋白 RBM25 通过调控转录因子 YY1 与染色质的结合，进而调控染色质结构和转录激活与抑制的分子机制，全面展示了特异性的 RNA 结合蛋白介导的转录因子 YY1 的功能调控作用。整个发现提出了 RNA 结合蛋白作为转录因子或辅助因子调控转录的新概念，也开辟了 RNA 结合蛋白功能研究的新领域。Controlling Visually Guided Behavior
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