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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
RAB14, member RAS oncogene family
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
RAB14, member RAS oncogene family
- 抗体英文名:
anti-RAB14 antibody,RAB14 antibody
- 抗体名:
anti-RAB14 抗体,RAB14 抗体
- 规格:
100μg
RAB14抗体| RAB14 antibody
货号 PAab06996
蛋白别名
蛋白介绍
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion.
产品描述
anti-RAB14 antibody is a Rabbit Polyclonal antibody againstRAB14..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using PAab06996( RAB14 Antibody) at dilution of 1:50
Western blot
human brain tissue were subjected to SDS PAGE followed by western blot with PAab06996(RAB14 antibody) at dilution of 1:500(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验PNAS:RAS 抑制剂又添一员,新型蛋白模拟物或为癌症治疗
13、RAB10、RAB14、RAB18、RAB5C 和 RAP1B)。序列分析表明,在 Sos 螺旋发夹结合区富集的 Ras 相关蛋白和其他 G 蛋白之间存在高度的序列相似性。图片来源:PNAS总的来说,该研究开发了一种 Sos 蛋白模拟物,它结合野生型和突变型 Ras,并对致癌 Ras 细胞具有选择性毒性作用。这种模拟物将为开发高 Ras 突变型癌症靶向抑制剂提供坚实的理论依据。延伸阅读该研究是同一团队十年前报道的跟进研究。图片来源:ScienceDirect 截图2011 年,Paramjit S
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