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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
BCL2 binding component 3
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IP
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
BCL2 binding component 3
- 抗体英文名:
anti-PUMA antibody,PUMA antibody
- 抗体名:
anti-PUMA 抗体,PUMA 抗体
- 规格:
100μg
PUMA抗体| PUMA antibody
货号 PAab06956
蛋白别名
蛋白介绍
产品描述
anti-PUMA antibody is a Rabbit Polyclonal antibody againstPUMA..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验Assays to Measure p53-Dependent and -Independent Apoptosis
. Current chemotherapeutic strategies manipulate this property by damaging cells and turning on p53’s transcriptional function, which consequently upregulates the expression of proapoptotic proteins such as Puma. We have also demonstrated that Puma
p53 引起细胞凋亡的机制 作为转录因子,p53可激活上百种基因表达,这些户53靶基因直接参与细胞周期的调控、DNA损伤的修复,以及细胞衰老、分化及细胞 凋亡的调控。发现p53靶基因对p53功能研究至关重要。cDNA差异显示技术和DNA芯片技术的应用对p53靶基因的发现提供了巨大帮助。目前发现的参与细胞凋亡调控的夕53靶基因已有数十种,可大致分为以下几类:死亡受体类,如Fas和DR5/killer;Bcl―2家族,如baa:、Noma、puma、PTEN和IGF―BPl
Identification and Validation of the Cellular Targets of Virus-Encoded MicroRNAs
. Our demonstration of the targeting of p53 upregulated modulator of apoptosis (PUMA) by an EBV-encoded viral miRNA provides one mechanism by which a viral miRNA facilitates viral replication by promoting cell survival. Using EBV miRNAs as an example, in this chapter
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