- ￥2262
- LSM Bio
- 进口
- PAab06954
- 2025年07月14日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
poly-U binding splicing factor 60KDa
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
poly-U binding splicing factor 60KDa
- 抗体英文名：
anti-PUF60 antibody,PUF60 antibody
- 抗体名：
anti-PUF60 抗体,PUF60 抗体
- 规格：
100μg
PUF60抗体| PUF60 antibody
货号 PAab06954
蛋白别名 FIR antibody, ROBPI antibody, SIAHBP1
蛋白介绍
DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.
产品描述
anti-PUF60 antibody is a Rabbit Polyclonal antibody againstPUF60..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human colon cancer using PAab06954(PUF60 antibody) at dilution of 1:100
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab06954(PUF60 antibody) at dilution of 1:800(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验367, ZNF177, CBX7, ZNF615, DPF1, ZNF169, GFI1B, OVOL1, GATAD2B, TWIST2, FOXD4, CHD3, ZNF548, ZBTB46, BRF2, TRIM29, SOX12, CDK9, DACH1, NR4A3, SPEN, HDAC11, HMGA1, NRIP2, CCR6, PRDM4, MED8, PARP14, ZNF384, RFX3, LRPPRC, PUF60, MED1 37
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