- ￥2262
- LSM Bio
- 进口
- PAab06936
- 2025年07月14日
- ELISA,WB,IHC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
- 抗体英文名：
anti-PTPN22 antibody,PTPN22 antibody
- 抗体名：
anti-PTPN22 抗体,PTPN22 抗体
- 规格：
100μg
PTPN22抗体| PTPN22 antibody
货号 PAab06936
蛋白别名 PTPN8
蛋白介绍
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr- 493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro- inflammatory cytokine secretion and autophagy (PubMed:23991106).
产品描述
anti-PTPN22 antibody is a Rabbit Polyclonal antibody againstPTPN22..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human lymphoma using PAab06936(PTPN22 antibody) at dilution of 1:50
Western blot
Jurkat cells were subjected to SDS PAGE followed by western blot with PAab06936(PTPN22 antibody) at dilution of 1:600(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis
according to the disease risk. Illustration is given on two susceptibility factors to Rheumatoid Arthritis: HLA and PTPN22. In both cases, thanks to the sharing of parental alleles in affected sibs, a refining of the modeling was obtained. Tezenas du Montcel et al
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