相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC,IF,IP
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
- 抗体英文名:
anti-PSME3 antibody,PSME3 antibody
- 抗体名:
anti-PSME3 抗体,PSME3 抗体
- 规格:
100μg
PSME3抗体| PSME3 antibody
货号 PAab06896
蛋白别名
蛋白介绍
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).
产品描述
anti-PSME3 antibody is a Rabbit Polyclonal antibody againstPSME3..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human colon cancer using PAab06896(PSME3 antibody) at dilution of 1:50
Western blot
human colon tissue were subjected to SDS PAGE followed by western blot with PAab06896(PSME3 antibody) at dilution of 1:500(本抗体仅供体外科研用途,不可用于临床诊断!) "">
""> ""> ""> ""> ""> "">风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验「体温低」竟能更长寿!Nature Aging 研究揭示低温延寿的关键机制
线虫(Caenorhabditis elegans)中,低温(15℃)能促进激活因子 PSME-3 介导的蛋白酶活性,而且 PSME-3 的表达能延长寿命。研究还表明,将体外培养的人类细胞暴露在适度偏低的体温(36℃)下,能激活人类版本的 PSME-3,并有望减少疾病相关的蛋白质改变。 图片来源:Nature Aging 主要研究内容 寒冷诱导的 PA28γ/PSME3 触发蛋白酶体活性 蛋白酶体(一类蛋白质复合物)可以通过降解不需要的、损坏的和错误折叠的易于聚集的蛋白质,包括与疾病相关的突变蛋白,来预防衰老和病理
技术资料暂无技术资料 索取技术资料







