- ￥2860
- LSM Bio
- 进口
- PAab06792
- 2025年07月16日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
protein arginine methyltransferase 6
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
protein arginine methyltransferase 6
- 抗体英文名：
anti-PRMT6 antibody,PRMT6 antibody
- 抗体名：
anti-PRMT6 抗体,PRMT6 抗体
- 规格：
100μg
PRMT6抗体| PRMT6 antibody
货号 PAab06792
蛋白别名 HRMT1L6
蛋白介绍
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting- induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).
产品描述
anti-PRMT6 antibody is a Rabbit Polyclonal antibody againstPRMT6..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human breast cancer using PAab06792(PRMT6 antibody) at dilution of 1:100
Western blot
human brain tissue were subjected to SDS PAGE followed by western blot with PAab06792(PRMT6 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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