- ￥2262
- LSM Bio
- 进口
- PAab06791
- 2025年07月16日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
protein arginine methyltransferase 5
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
protein arginine methyltransferase 5
- 抗体英文名：
anti-PRMT5 antibody,PRMT5 antibody
- 抗体名：
anti-PRMT5 抗体,PRMT5 抗体
- 规格：
100μg
PRMT5抗体| PRMT5 antibody
货号 PAab06791
蛋白别名 HRMT1L5 antibody, IBP72 antibody, JBP1 antibody, SKB1
蛋白介绍
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805).
产品描述
anti-PRMT5 antibody is a Rabbit Polyclonal antibody againstPRMT5..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human testis tissue slide using PAab06791( PRMT5 Antibody) at dilution of 1:50
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab06791( PRMT5 Antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验3, mouse CARM1 (PRMT4), human JBP1 (PRMT5). Substrates of PRMTs: In mammalian cells hnRNPs contain about 65% of the total NG,NG-dimethylarginine found in the cell nucleus. Additionally, functionally diverse proteins are substrates for PRMT family
10.21 华中科技大学 Nature 子刊揭示精母细胞中逆转录转座子沉默的分子机制
and cooperates with PRMT5 and PIWI proteins in male germ cells ② Science 揭示基因 Shisa7 控制着苯二氮平类药物的镇定神经作用在 1999 年至 2017 年之间，在美国因过量服用安定（Valium，又称为苯甲二氮，或地西泮）和其他苯二氮平类药物死亡的人数增加了 10 倍。多年以来，科学家们一直认为，这些用于治疗焦虑症、肌肉痉挛和睡眠障碍的强效镇静剂独自地起着镇定神经的作用。如今，在一项新的研究中，来自美国国家卫生研究院（NIH）的研究人员发现
Using ProHits to Store, Annotate, and Analyze Affinity Purification–Mass Spectrometry (AP‐MS) Data
at the protein comparison page, or for a selected protein, as shown here. (C ) Sample Report: Here, only the deamidated peptides from the protein PRMT5 were exported to a .csv or .tsv file. View Image
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