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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human, Mouse
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,IP,WB
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
- 抗体英文名:
anti-PPARGC1B antibody,PPARGC1B antibody
- 抗体名:
anti-PPARGC1B 抗体,PPARGC1B 抗体
- 规格:
100μg
PPARGC1B抗体| PPARGC1B antibody
货号 PAab06666
蛋白别名 PERC antibody, PGC1 antibody, PGC1B antibody, PPARGC1
蛋白介绍
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
产品描述
anti-PPARGC1B antibody is a Rabbit Polyclonal antibody againstPPARGC1B..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验出PKD1、PPARGC1B、KMT2D和ARID1A基因发生频发突变(recurrent mutation)。细胞突变体克隆的数量和大小随着肝脏纤维化阶段和组织损伤的增加而增加。为了研究突变基因的功能影响,这些研究人员建立了一种合并的体内CRISPR筛选方法。与测序结果一致的是,对147个基因的检测再次表明Pkd1、Kmt2d和Arid1a的缺失促进了克隆扩增。在小鼠中,这些基因的条件性杂合缺失在组织损伤检测中也具有保肝作用。癌变前的体细胞突变通常从癌症的视角来观察,但是他们证实突变能够促进肝脏
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