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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
polymerase (DNA directed) iota
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC,IP
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
polymerase (DNA directed) iota
- 抗体英文名:
anti-POLI antibody,POLI antibody
- 抗体名:
anti-POLI 抗体,POLI 抗体
- 规格:
100μg
POLI抗体| POLI antibody
货号 PAab06612
蛋白别名 RAD30B
蛋白介绍
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
产品描述
anti-POLI antibody is a Rabbit Polyclonal antibody againstPOLI..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human pancreas cancer using PAab06612(POLI antibody) at dilution of 1:100
Western blot
mouse testis tissue were subjected to SDS PAGE followed by western blot with PAab06612(POLI antibody) at dilution of 1:800(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验Varanasi, Jesse W Williams, Michael C Jagoda, Emily C Bellavance, Amanda L Marzo, Paul G Thomas, Biljana Zafirova, Bojan Polić, Lena Al-Harthi, Anne I Sperling & José A Guevara-Patiño CD4-unhelped CD8+ T cells are functionally defective T cells primed
用于治疗AIDS。目前多使用AZT或双脱氧肌苷等作为治疗药物,同时也在不断开发新的抗HIV病毒药物。但是这些药物和抗生素一样出现了HIV病毒的耐药菌株,为了解决耐药性的问题需要开发出作用机制不同的药物。由于干扰素具有抗病毒作用和增强免疫的功能,可作为治疗AIDS的辅助药物。Poli的实验表明干扰素能抑制HIV病毒在慢性感染细胞系中的表达。在英国,α干扰素已获批准治疗AIDS有关的KS。 1 大剂量干扰素治疗和AIDS有关的KS KS是AIDS的显著临床特征,是发生在HIV抗体
as a chimeric antibody by means of a mammalian expression vector. Proc.Casadei, J. et al. (1990).Natl. Acad. Sci. U. S. A. 87, 2047–2051. 13. Fully automated chemiluminescence immunoassay of insulin using antibody–protein A–bacterial magnetic particle complexes
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