- ￥2262
- LSM Bio
- 进口
- PAab06550
- 2025年07月15日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
polo-like kinase 4 (Drosophila)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
polo-like kinase 4 (Drosophila)
- 抗体英文名：
anti-PLK4 antibody,PLK4 antibody
- 抗体名：
anti-PLK4 抗体,PLK4 抗体
- 规格：
100μg
PLK4抗体| PLK4 antibody
货号 PAab06550
蛋白别名 SAK antibody, STK18
蛋白介绍
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
产品描述
anti-PLK4 antibody is a Rabbit Polyclonal antibody againstPLK4..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human testis using PAab06550(PLK4 antibody) at dilution of 1:200
Western blot
mouse lung tissue were subjected to SDS PAGE followed by western blot with PAab06550(PLK4 antibody) at dilution of 1:2000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
""> ""> ""> ""> ""> "">风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验三句话读懂一篇 CNS，一周科研聚焦：「天作之合」的生物学原理，首次体外三维模拟人体发育模型...
吸收过程中会与肠道中的微生物发生作用，而微生物对药物的代谢物也会影响药物的药效。Cell 刊登的这篇文章提供了一个定量实验方案，MDM-Screen，可以用来评估口服药物的代谢情况。 6. 特立独行的中心粒如何受到调控中心粒在细胞有丝分裂过程中发挥重要的作用，中心粒的发生受 Plk4（Polo-like kinase 4）调控，而 Plk4 的表达又受到 Asl（Asterless）的负反馈调节。有趣的是，Plk4 对中心粒的周期性调控可以不受细胞周期的影响，即使细胞周期受到干扰，Plk4 也可以调控中心
技术资料暂无技术资料 索取技术资料
