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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
phosphatidylinositol 4-kinase type 2 beta
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC,IF
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
phosphatidylinositol 4-kinase type 2 beta
- 抗体英文名:
anti-PI4K2B antibody,PI4K2B antibody
- 抗体名:
anti-PI4K2B 抗体,PI4K2B 抗体
- 规格:
100μg
PI4K2B抗体| PI4K2B antibody
货号 PAab06425
蛋白别名
蛋白介绍
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
产品描述
anti-PI4K2B antibody is a Rabbit Polyclonal antibody againstPI4K2B..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human liver using PAab06425(PI4K2B antibody) at dilution of 1:100
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab06425(PI4K2B antibody) at dilution of 1:400(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验Immunity:北大蒋争凡课题组发现 STING 后高尔基体囊泡转运的重要性及机制
高尔基体(trans-Golgi network, TGN)上的含量最高。细胞中的 PI4P 的含量主要受其合成酶 PI4Ks (PI4KA, PI4KB, PI4K2A 和 PI4K2B) 和降解酶 SAC1 的调控。PI4P 不仅是合成 PIP2 和 PIP3 的前体,也是重要的信号分子,在膜泡运输、脂质转运和细胞器形态维持等方面发挥关键作用。 2021 年蒋争凡实验室利用 STING 自激活突变体诱导细胞死亡的特性,在 HT080 细胞中进行了基于 CRISPR-Cas9 介导的全基因组筛选
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