- ￥2262
- LSM Bio
- 进口
- PAab06277
- 2025年07月16日
- ELISA,WB,IHC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
pyruvate dehydrogenase kinase, isozyme 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
pyruvate dehydrogenase kinase, isozyme 2
- 抗体英文名：
anti-PDK2 antibody,PDK2 antibody
- 抗体名：
anti-PDK2 抗体,PDK2 抗体
- 规格：
100μl
PDK2抗体| PDK2 antibody
货号 PAab06277
蛋白别名 PDHK2
蛋白介绍
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
产品描述
anti-PDK2 antibody is a Rabbit Polyclonal antibody againstPDK2..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human brain using PAab06277(PDK2 antibody) at dilution of 1:100
Western blot
human heart tissue were subjected to SDS PAGE followed by western blot with PAab06277(PDK2 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验相关专题 Akt1, also known as "Akt" or protein kinase B (PKB). Its signalling pathway is as follows: 1. Binds to phospholipids in the membrane 2. Phosphorylation by PDK1 and PDK2 3. Lipid phosphatases
releases CTMP from AKT and allows AKT to be phosphorylated by PDK1 and PDK2 at Thr308 and Ser473, respectively. Phosphorylation at these two sites causes full activation of AKT. C2, C2 domain; CD, catalytic domain; p85 BD, p85-binding domain. Nature
, 一种是与具有磷酸化酪氨酸残基的生长因子受体或连接蛋白相互作用, 引起二聚体构象改变而被激活; 另一种是通过Ras和p110直接结合导致PI3K的活化. PI3K激活的结果是在质膜上产生第二信使PIP3, PIP3与细胞内含有PH结构域的信号蛋白Akt和PDK1(phosphoinositidedependentkinase-1)结合, 促使PDK1磷酸化Akt蛋白的Ser308导致Akt的活化. Akt还能通过PDK2(如整合素连接激酶ILK)对其Thr473的磷酸化而被激活.活化的Akt通过磷酸
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