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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
oxysterol binding protein
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
Q9WVH4
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC,IP
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
oxysterol binding protein
- 抗体英文名:
anti-OSBP antibody,OSBP antibody
- 抗体名:
anti-OSBP 抗体,OSBP 抗体
- 规格:
100μl
OSBP抗体| OSBP antibody
货号 PAab06016
蛋白别名 OSBP1
蛋白介绍
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).
产品描述
anti-OSBP antibody is a Rabbit Polyclonal antibody againstOSBP..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human ovary tumor using PAab06016(OSBP antibody) at dilution of 1:50
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab06016(OSBP antibody) at dilution of 1:800(本抗体仅供体外科研用途,不可用于临床诊断!) <"">
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文献和实验Immunity:北大蒋争凡课题组发现 STING 后高尔基体囊泡转运的重要性及机制
的 pH 值有利于 STING 与 sGAGs 的结合,他们推测 PI4P 可以通过指导 AP-1 和 GGA2 介导的 clathrin-coated vesicles (CCVs) 将 STING 从高尔基体转运到内体从而避免 STING 被运回内质网,并且更加强烈激活 STING。另一类 PI4P 结合蛋白均为脂质转运蛋白,其中 OSBP 和 ORPs 负责从内质网向高尔基体或内体转运胆固醇,CERT 负责神经酰胺从内质网到高尔基体的转运。神经酰胺在高尔基体上会在 SGSM1 的催化下转
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