- ￥2062
- LSM Bio
- 进口
- PAab01660
- 2025年07月14日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human, Mouse , Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
chromatin modifying protein 4B
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse , Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9GZT9
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
CHMP4B
- 抗体英文名：
anti-CHMP4B antibody,CHMP4B antibody
- 抗体名：
anti-CHMP4B 抗体,CHMP4B 抗体
- 规格：
100μg
CHMP4B抗体| CHMP4B antibody
货号 PAab01660
蛋白别名 C20orf178 antibody, SHAX1
蛋白介绍
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9- dependent virus release.
产品描述
anti-CHMP4B antibody is a Rabbit Polyclonal antibody againstCHMP4B..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human oesophagus cancer using PAab01660(CHMP4B antibody) at dilution of 1:50
Western blot
mouse heart tissue were subjected to SDS PAGE followed by western blot with PAab01660(CHMP4B antibody) at dilution of 1:200(本抗体仅供体外科研用途，不可用于临床诊断!)
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文献和实验
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