Human Immediate early response

Identification of ImmediateEarly Gene Targets of the Raf-1 Serine/Threonine Protein Kinase Using an Estradiol-Dependent Fusion Protein, Raf-1:ER

involve changes in gene expression, we have employed a conditional form of the Raf-1 protein kinase (5 ) in conjunction with differential display PCR (6 ,7 ) to identify immediate-early target genes of Raf-1 signaling.

Analysis of Protein-DNA Interactions During Cytomegalovirus Infection

from the major IE gene region (6 ,7 ). This enhancer-promoter can both be regulated by cellular proteins such as transcription factors of the ATF/CREB and NF-κ-B family and viral proteins such as the tegument constituents pp71 and ppUL69 or the immediate early protein

Analysis of Anti-Interferon Properties of the Herpes Simplex Virus Type I ICP0 Protein

-1) is a large deoxyribonucleic acid virus best known for its ability to cause cold sores in infected individuals. In cultured cells, HSV-1 is relatively resistant to the effects of IFNs. Plaque reduction assays were used to determine that the immediate early HSV