BIRB 796

Description: High affinity and selective p38 kinase inhibitor
Alternative Names: Doramapimod
Chemical Name: N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
Biological Activity
BIRB 796 is a high affinity and selective p38 kinase inhibitor (K_d = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC₅₀ values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC₅₀ values are 98 nM and 1.4 μM, respectively). BIRB 796 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs. Cell permeable.
Technical Data
M.Wt:527.66
Formula:C₃₁H₃₇N₅O₃
Solubility:Soluble to 100 mM in DMSO
Purity:≥98%
Storage:Store at -20°C
CAS No:285983-48-4

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