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文献和实验Cytotoxic T Lymphocytes in SV40 Infections
specific for the large tumor antigen, or T antigen (T-ag) encoded by SV40. In addition, the T-ag in transformed or tumor cells also serves as the target for cytotoxic T lymphocytes (CTL) that are capable of controlling tumor development (2 ). CTL responses
Biology of p53 and SV40 Large T Association
p53 was discovered because of its capacity to bind to SV40 large T antigen (SVLT) in transformed cell lines (1 ,2 ). It is a phosphorylated, 393 amino acid protein, with five blocks of sequences that are highly conserved
Role of SV40 Small t in Cell Lysis, Transformation, and Signaling
Simian virus 40 small t antigen (st) is encoded on a differentially spliced transcript of the SV40 early region. It shares its aminoterminal 82 amino acids with the large T antigen and contains a unique cysteine-rich carboxyterminal half
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