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文献和实验【进展|热点】Nature Immunology:骨髓基质细胞通过细胞间接触分泌SDF-1
Nature Immunology | Article 2011 Mar 27. [Epub ahead of print]CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctionsAmir Schajnovitz, et al.1 Department of Immunology
Split Gaussia Luciferase for Imaging LigandReceptor Binding
. While we illustrate this imaging method for chemokine ligand CXCL12 and its receptors CXCR4 and CXCR7, this imaging strategy can be generalized to a large number of ligand–receptor interactions.
Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis
The hallmark of hematopoietic stem and progenitor cells (HSPCs) is their motility, which is essential for their function, such as recruitment upon demand. Stromal Derived Factor-1 (SDF-1, CXCL12) and its major receptor CXCR4 play major roles
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