C4D RMABMA553097

Simultaneous Determination of Atenolol and Amiloride by Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection (C4D)

Capillary electrophoresis coupled with a capacitively coupled contactless conductivity detector (CE-C4 D) has been employed for the determination of the β-blocker drugs (atenolol and amiloride) in pharmaceutical formulations

Solid Phase Assay Measuring C4d Deposition to Determine Complement Fixation by HLA-Specific Antibodies

The definition of HLA-specific antibodies in solid organ transplant patients is a necessary tool for recipient selection prior to transplantation and monitoring for rejection post transplant. Solid phase assays can detect both complement

补体调节蛋白

酶的形成和促使其解离：如DAF(CD55)、C4BP、CRl(CD35)等，可竞争性结合C4b，使C4b不能和C2b结合，C3转化酶(C4b2b)形成受阻。而调节因子中的I因子，以及对其起促进作用的H因子及MCP(CD46)则促使C3转化酶中的C4b分解为C4c和C4d，或者使C5转化酶(C4b2b3b)中的C3b分解为C3c和C3dg，其结果，补体级联反应难以持续。       (3)抑制攻膜复合物的形成：主要是HRF和MIRL(CD59)，机制是阻抑C56678与C9结合。