PF 184

1) Cat. No.: TRC-P293750; 2) Chemical Name: PF 184; 3) CAS No.: 1187460-81-6; 4) Mol. Formula: C32H32ClFN6O4; 5) Mol. Weight: 619.09; 6) Packing Size: 10mg / 100mg; 7) Appearence: ; 8) Application Notes: PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress. ; 9) Synonym: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide; ; 10) Solubility: ; 11) Storage condition: ; 12) References: Baldwin, A., et al.: J. Clin. Invest., 107, 3 (2001), Adcock, I., et al.: Eur. J. Pharmacol., 533, 118 (2006), Sommers, et al.: J. Pharmacol. Exp. Ther., 330 377 (2009),