- ￥5273
- BioLegend
- 345034
- 美国
- 2025年07月15日
- 免疫荧光，流式
- 小鼠
- 人
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- 技术资料
- 抗体名：
PE/Dazzle™ 594 anti-human CD366 (Tim-3)
- 抗体英文名：
PE/Dazzle™ 594 anti-human CD366 (Tim-3)
- 应用范围：
免疫荧光，流式
- 宿主：
小鼠
- 供应商：
上海善然生物
- 库存：
现货
- 抗原来源：
小鼠
- 适应物种：
人
- 标记物：
PE/Dazzle™ 594
- 克隆性：
单克隆
- 保存条件：
2-8度
- 形态：
液体
- 规格：
100 tests
PE/Dazzle™ 594 anti-human CD366 (Tim-3) Antibody
F38-2E2
Catalog# / Size 345033 / 25 tests
345034 / 100 tests
Clone
Regulatory Status RUO
Workshop HCDM listed
Other Names T cell immunoglobulin and mucin domain containing protein 3, hepatitis virus cellular receptor 2,
CD366
Isotype Mouse IgG1, κ
Description CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin
domain containing protein-3. Tim-3 is expressed at high levels on activated T cells
(preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also
been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in
the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a
disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to
inhibit Th1-mediated immune responses and promote immunological tolerance.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Human Tim-3 fusion protein
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under
optimal conditions.
Concentration Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our
Certificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from
prolonged exposure to light. Do not freeze.
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3敢和PD-1并驾齐驱，TIM3到底是何方神圣? TIM全名T淋巴细胞免疫球蛋白黏蛋白（T cell immunoglobulin mucin），还有个洋气的名字CD366，是2002年money等[6]在研究哮喘易感基因的过程中发现的。人类TIM家族只包括TIM1、TIM3和TIM4，位于5号染色体5q33.3上，TIM分子的共同结构包括：免疫球蛋白N末端可变区、粘蛋白结构域、跨膜区和胞内区。 图片来源于：http://www.genecards.org/cgi
来瓶「红牛」继续干！唐力团队发现 IL-10 可激活终末耗竭 T 细胞，为增强肿瘤免疫治疗提供新思路
exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity 的研究成果。该研究发现，IL-10 通过上调线粒体丙酮酸载体依赖的氧化磷酸化，从而介导 T 细胞代谢重编程，进而恢复终末耗竭 T 细胞的活力，并增强癌症免疫治疗的反应。 图片来源：Nature Immunology研究内容IL-10 直接扩增终末耗竭的 CD8 + 细胞作者首先制备了重组的人 IL-10 和 IgG1 Fc 的融合蛋白（IL-10–Fc），该蛋白可以与小鼠 IL-10 受体
Cell Surface Immunofluorescence Staining Protocol
-CD4-Biotin, and anti-CD8-APC) and incubate on ice for 15-20 minutes in the dark. 9) Wash 2X with at least 2 ml of Cell Staining Buffer by centrifugation at 350 x g for 5 minutes. 1) If using a purified primary antibody, resuspend
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