InvivoCrown In vivo CTLA-4 neu

InVivoPro Anti-Mouse NK1.1(CD161) Antibody in vivo antibody, Clone PK136InVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9H10Mouse IgG2a κSyrian hamster IgGPK1369H10NK1.1CTLA-4CD161 antigen, CD161, CD161/NK1.1cytotoxic T-lymphocyte antigen 4, CTLA-4, CD152Mouse IgG2a Isotype ControlSyrian hamster lgG Isotype ControlPBS, pH 7.2, contains no stabilizers or preservativesPBS, pH 7.2, contains no stabilizers or preservativesMouseMouseMouseSyrian hamster200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the PK136 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.200-300 μg per mouse; or 10-15 mg/kg. This range is based off the most recent publication data using the 9H10 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.267176Andre, Pascale et al. "Anti-NKG2A Mab is a Checkpoint Inhibitor That Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells",Cell 175.7 (2018): 1731-+. Biswas, Subir et al. "IgA Transcytosis and Antigen Recognition Govern Ovarian Cancer Immunity.",Nature 591.7850 (2021): 464-470. Deng, Zihou et al. "The Nuclear Factor ID3 Endows Macrophages with a Potent Anti-Tumour Activity",NATURE 626.8000 (2024)Gao, Jianjun et al. "Loss of IFN-γ Pathway Genes in Tumor Cells As a Mechanism of Resistance to Anti-CTLA-4 Therapy.",Cell 167.2 (2016): 397-404.e9. Benci, Joseph L. et al. "Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.",Cell 167.6 (2016): 1540-1554.e12. Jerby-Arnon, Livnat, et al. "A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade." Cell 175.4 (2018): 984-997.NK-1.1 surface antigen, also known as CD161b/CD161c, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. Clone 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA4 binding, allowing for CD28 binding.In vivo NK cell depletion, Flow cytometryIn vivo CTLA-4 neutralizationprotein A or Gprotein A or GThis antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.2-8°C with blue ice2-8°C with blue iceLot specific, generally ≥ 5.0 mg/mlLot specific, generally ≥ 5.0 mg/ml12 months from the date of receipt if stored as recommended12 months from the date of receipt if stored as recommendedPBS Buffer, PH 7.2, with no carrier protein, or preservatives.PBS Buffer, PH 7.2, with no carrier protein, or preservatives.0.2 μM filtered0.2 μM filtered≤ 1.0 EU/mg, by the LAL method≤ 1.0 EU/mg, by the LAL method0.990.99可替换BioXCell产品货号为BE0131