InvivoCrown In vivo TNFα neutr

InVivoPro Anti-Mouse TNFα in vivo antibody, Clone TN3-19.12InVivoPro Anti-Mouse TNFα in vivo antibody, Clone TN3-19.12Armenian Hamster IgGArmenian Hamster IgGTN3-19.12TN3-19.12TNFαTNFαTNF-alpha, TNFSF2, Tnlg1fTNF-alpha, TNFSF2, Tnlg1fArmenian Hamster IgG Isotype ControlArmenian Hamster IgG Isotype ControlPBS, pH 7.2, contains no stabilizers or preservativesPBS, pH 7.2, contains no stabilizers or preservativesMouseMouseArmenian HamsterArmenian Hamster200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the TN3-19.12 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the TN3-19.12 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.1212Dudek, Michael et al. "Auto-aggressive CXCR6+ CD8 T Cells Cause Liver Immune Pathology in NASH",Nature (2022) Gulen, Muhammet F. et al. "Cgas–sting Drives Ageing-Related Inflammation and Neurodegeneration",Nature 620.7973 (2023): 374-380. Ma, Leyuan et al. "Vaccine-boosted CAR T Crosstalk with Host Immunity to Reject Tumors with Antigen Heterogeneity",Cell (2023)Dudek, Michael et al. "Auto-aggressive CXCR6+ CD8 T Cells Cause Liver Immune Pathology in NASH",Nature (2022) Gulen, Muhammet F. et al. "Cgas–sting Drives Ageing-Related Inflammation and Neurodegeneration",Nature 620.7973 (2023): 374-380. Ma, Leyuan et al. "Vaccine-boosted CAR T Crosstalk with Host Immunity to Reject Tumors with Antigen Heterogeneity",Cell (2023)The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity. It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. TNF-alpha is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-alpha secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-alpha has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-alpha.The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity. It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. TNF-alpha is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-alpha secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-alpha has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-alpha.In vivo TNFα neutralization, Enzyme-linked Immunosorbent AssayIn vivo TNFα neutralization, Enzyme-linked Immunosorbent Assayprotein A or Gprotein A or GThis antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.2-8°C with blue ice2-8°C with blue iceLot specific, generally ≥ 5.0 mg/mlLot specific, generally ≥ 5.0 mg/ml12 months from the date of receipt if stored as recommended12 months from the date of receipt if stored as recommendedPBS Buffer, PH 7.2, with no carrier protein, or preservatives.PBS Buffer, PH 7.2, with no carrier protein, or preservatives.0.2 μM filtered0.2 μM filtered≤ 1.0 EU/mg, by the LAL method≤ 1.0 EU/mg, by the LAL method0.990.99可替换BioXCell产品货号为BE0058