InvivoCrown In vivo CD8+ T cel

InVivoPro Anti-Mouse Ly6G in vivo antibody, Clone 1A8InVivoPro Anti-Mouse CD8α in vivo antibody, Clone 2.43Rat IgG2a κRat IgG2b1A82.43Ly6GCD8αGr1，Gr-1，Ly-6GCD8 alpha chain，Ly 2.2，Ly-35IV0105 or Rat IgG2a Isotype Control IV0106 or Rat IgG2b Isotype Control PBS, pH 7.2, contains no stabilizers or preservativesPBS, pH 7.2, contains no stabilizers or preservativesMouseMouseRatRat100-500 μg per mouse; or 5 mg/kg. This range is based off the most recent publication data using the 1A8 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.200-500 μg per mouse; or 10 mg/kg. This range is based off the most recent publication data using the 2.43 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.264440Uderhardt, Stefan et al. "Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.",Cell 177.3 (2019): 541-555.e17. Xue, Ruidong et al. "Liver Tumour Immune Microenvironment Subtypes and Neutrophil Heterogeneity.",Nature 612.7938 (2022): 141-147. Sang, Di et al. "Prolonged Sleep Deprivation Induces a Cytokine-Storm-like Syndrome in Mammals.",CELL 186.25 (2023)Sade-Feldman, Moshe et al. "Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma",Cell 175.4 (2018): 998-1013.e20. Krishnamurty, Akshay T. et al. "LRRC15 + Myofibroblasts Dictate the Stromal Setpoint to Suppress Tumour Immunity",Nature 611.7934 (2022): 148-154. Fan, Hao et al. "Trans-vaccenic Acid Reprograms CD8+ T Cells and Anti-Tumour Immunity.",NATURE 623.7989 (2023): 1034-+.Ly-6G is a 21-25 kD GPI-anchored protein, is expressed on the majority of myeloid cells in bone marrow and peripheral granulocytes.Ly6G antibody (clone 1A8) recognizes an epitope on mouse Ly6G. Clone 1A8 does not cross react with Ly6C.CD8 is part of the Ig superfamily that expresses primarily as CD8α homodimers. CD8α is a 32-34 kD type I glycoprotein that can also form heterodimers with CD8β. Clone 2.43 recognizes an epitope on mouse CD8a.In vivo neutrophil depletion, in vivo MDSC depletion, Flow cytometry, Immunohistochemistry(Paraffin and Frozen)In vivo CD8+ T cell depletion, Flow cytometryprotein A or Gprotein A or GThis antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.2-8°C with blue ice2-8°C with blue iceLot specific, generally ≥ 5.0 mg/mlLot specific, generally ≥ 5.0 mg/ml12 months from the date of receipt if stored as recommended12 months from the date of receipt if stored as recommendedPBS Buffer, PH 7.2, with no carrier protein, or preservatives.PBS Buffer, PH 7.2, with no carrier protein, or preservatives.0.2 μM filtered0.2 μM filtered≤ 1.0 EU/mg, by the LAL method≤ 1.0 EU/mg, by the LAL method0.990.99可替换BioXCell产品货号为BE0061