Alexa Fluor® 488 anti-mouse TC

Alexa Fluor® 488 anti-mouse TCR γ/δ Antibody
UC7-13D5
Catalog# / Size 107512 / 100 µg
Clone
Regulatory Status RUO
Other Names TCR-γ/δ, γ/δ TCR
Isotype Armenian Hamster IgG
Description T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a
δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the
recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ
associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal
epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are
CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role
in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported
that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5
antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete
peripheral TCR-γ/δ-bearing T cells in vivo.
Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Armenian Hamster
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under
optimal conditions.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from
prolonged exposure to light. Do not freeze.