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- 优爱
- 江苏南京
- UA011148
- 2026年01月31日
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| 规格： | 25μg | 产品价格： | ￥1280.0 |
|---|---|---|---|
| 规格： | 100μg | 产品价格： | ￥2800.0 |
| 规格： | 500μg | 产品价格： | ￥9240.0 |
Notch3 is one of the four mammalian Notch proteins that serve as signaling receptors and are involved in developmental patterning, cell fate decisions, and the regulation of cell survival and proliferation. Notch3 interacts with membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell fate determination. Upon ligand activation, the Notch intracellular domain (NICD) is released and forms a transcriptional activator complex with RBPJ/RBPSUH, which in turn activates genes within the enhancer of split locus. As a result, the activation of Notch3 can initiate differentiation, proliferation, and apoptotic programs.
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文献和实验cells. We present here (i) a detailed protocol for the production and purification of soluble recombinant NK cell receptors tagged with human IgG1-Fc (thus termed receptor-Fc chimera or receptor-Ig fusion protein) and (ii) a protocol for cell staining
【原创】Protein A Sepharose 之进化篇。。。
[img][/img]Protein A 柱之进化 Protein A是一种金黄色葡萄球菌细胞壁蛋白质，能特异性地与人和哺乳动物抗体（主要是IgG）的Fc区结合。因而，将Protein A 与琼脂糖凝胶以一定的方式结合，可制备用于抗体纯化的亲和填料。 早期的Protein A柱结合的都是天然Protein A。天然Protein A由5个IgG结合域和其它未知功能的非Fc结合域组成，分子量约42KD，结构如图1所示。这种柱子对IgG的亲和能力很强，可以吸附大量的lgG。但同时，天然
Transient Production of scFv-Fc Fusion Proteins in Mammalian Cells
Single chain Fv (scFv) antibody fragments fused to the human immunoglobulin G (IgG) Fc moiety obtain IgG-like properties, but nevertheless they are still encoded by a single gene. As transient production of scFv-Fc proteins in mammalians
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