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- 详细信息
- 技术资料
- 保存条件:
<p>12 months from date of receipt / reconstitution, -20 °C as supplied</p>
- 供应商:
斯达特
- 规格:
25μl/100μl/1ml
| 规格: | 25μl | 产品价格: | ¥600.0 |
|---|---|---|---|
| 规格: | 100μl | 产品价格: | ¥2100.0 |
| 规格: | 1ml | 产品价格: | ¥13200.0 |
ADAM10 is a sheddase, and has a broad specificity for peptide hydrolysis reactions. ADAM10 cleaves ephrin, within the ephrin/eph complex, formed between two cell surfaces. When ephrin is freed from the opposing cell, the entire ephrin/eph complex is endocytosed. In neurons, ADAM10 is the most important enzyme, with α-secretase activity for proteolytic processing of the amyloid precursor protein. ADAM10, along with ADAM17, cleaves the ectodomain of the triggering receptor expressed on myeloid cells 2 (TREM2), to produce soluble TREM2 (sTREM2), which has been proposed as a CSF and sera biomarker of neurodegeneration. ADAM10 being a major determinant of HER2 shedding, the inhibition of which, may provide a novel therapeutic approach for treating breast cancer and a variety of other cancers with active HER2 signaling.
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