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huayun / TGFβR2/ TGFBR2, Human

, Recombinant,HYPC5106
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  • ¥5340
  • 华韵生物(Huayunbio)
  • HYPC5106
  • 2025年07月14日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 供应商

      广州华韵生物科技有限公司

    • 规格

      10µg

    产品信息

    别名TGF-beta Receptor type-2; TGF-beta type II Receptor; TGFBR2; Transforming Growth Factor-beta Receptor type II
    物种Human
    表达宿主Human Cells
    序列信息Thr23-Asp159
    检索号P37173
    分子量42.6 kDa
    表观分子量59 kDa
    标签C-Fc
    生物活性 Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells. The ED50 for this effect is 18.41 ng/ml in the presence of 100pg/ml of recombinant human TGF-beta 1.

    产品特性

    纯度 >95% as determined by reducing SDS-PAGE.
    内毒素< 1.0 EU per µg as determined by LAL test.
    保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输 Ambient temperature or ice pack.
    制剂Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.
    复融Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    背景介绍

    TGFBR2 is a single-pass type I membrane Protein and contains one Protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another Receptor Protein and binds TGF-beta. Signals triggered through the TGF-beta Receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta Receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.

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    图标文献和实验
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