huayun / IL-7 (C-6His), Human, Recombinant,HYPC5094

huayun / IL-7 (C-6His), Human,

Recombinant,HYPC5094
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  • ¥5340
  • 华韵生物(Huayunbio)
  • HYPC5094
  • 2025年07月15日
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    • 详细信息
    • 技术资料
    • 供应商

      广州华韵生物科技有限公司

    • 规格

      10µg

    产品信息

    别名Interleukin-7; IL-7; IL7
    物种Human
    表达宿主Human Cells
    序列信息 Asp26-His177
    检索号P13232
    分子量18.4 kDa
    表观分子量19-30kDa
    标签C-6His
    生物活性 Measured in a cell proliferation assay using PHA-activated human peripheral blood mononuclear cell(PBMC). The ED50 for this effect is 50-300 pg/ml.

    产品特性

    纯度 >95% as determined by reducing SDS-PAGE.
    内毒素< 1.0 EU per µg as determined by LAL test.
    保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输 Ambient temperature or ice pack.
    制剂Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.
    复融Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    背景介绍

    Human Interleukin 7 (IL-7) is a potent lymphoid cell Growth Factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte Growth Factor (HGF) to form a hybrid Cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor Protein containing a 25 amino acid signal peptide and a 152 amino acid mature Protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 Receptor (IL7R) activating multiple pathways including JaK/ STAT and PI3K/ AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.

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