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文献和实验Evaluation of the Cardiac Isoform of 2-Macroglobulin as a Factor Inducing Cardiac Hypertrophy
cardiac hypertrophy upon direct injection into rat heart. Hypertrophy was monitored by determining the heart weight/body weight ratio and also by Northern blot analysis of muscle-specific marker genes such as -MHC, MLC-2, and antrial natriuretic factor
Multiple assays for Shh activity using cell lines, primary cultures, and explanted tissue have been described. We first described the use of E11.5 rat dorsal telencephalic explants to assay Shh ventralizing and differentiation-inducing
Experimental Systems to Study Neurotrophic Factor Effects on Rat Brain Cells
Nerve growth factor (NGF) was discovered and the concept of neurotrophic factors as retrograde messengers was developed in studies on the peripheral nervous system (PNS). Initial descriptions of biological effects of newly discovered grow
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